Looking for lotions that reduce signs of aging? Your best bet is to use products from reputable larger companies since they tend to have the most research to support them, says Doris Day, MD, author of Forget the Facelift. Don’t overpay for products that tout topical collagen or hyaluronic acid. When these ingredients are injected into the skin in a doctor’s office, they can plump up skin and smooth out wrinkles, but in a lotion they’ll merely moisturize.